Embolic middle cerebral artery occlusion model using thrombin and fibrinogen composed clots in rat
نویسندگان
چکیده
منابع مشابه
Embolic middle cerebral artery occlusion (MCAO) for ischemic stroke with homologous blood clots in rats.
Clinically, thrombolytic therapy with use of recombinant tissue plasminogen activator (tPA) remains the most effective treatment for acute ischemic stroke. However, the use of tPA is limited by its narrow therapeutic window and by increased risk of hemorrhagic transformation. There is an urgent need to develop suitable stroke models to study new thrombolytic agents and strategies for treatment ...
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Background: Stroke is the third leading cause of death. Hypothermia has been recognized as an effective method in reducing brain injury. In this study, we assessed the effects of granulocyte colony-stimulating factor (G-CSF) as a neuroprotective agent and mild hypothermia on mortality, behavioral function, infarct volume, and brain edema in Wistar rats. Methods: Forty male rats were used in fiv...
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Introduction: The embolic model of rat middle cerebral artery occlusion is widely used for preclinical testing of neuroprotective drugs. While the time course of the perfusion and diffusion lesion have been described, little data has been collected to describe the time course of clot lysis during tissue plasminogen activator (tPA) administration in this model. To provide another level of charac...
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Introduction: Cerebral ischemia is one of the most common causes of death in human populations in the industrial communities. The need for animal models is inevitable to study the pathophysiology and treatment of cerebral ischemia in human. The current study aimed at evaluating the strengths and weaknesses of different techniques used to create ischemia in previous studies and optimizing the tr...
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background: stroke is the third leading cause of death. hypothermia has been recognized as an effective method in reducing brain injury. in this study, we assessed the effects of granulocyte colony-stimulating factor (g-csf) as a neuroprotective agent and mild hypothermia on mortality, behavioral function, infarct volume, and brain edema in wistar rats. methods: forty male rats were used in fiv...
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ژورنال
عنوان ژورنال: Journal of Neuroscience Methods
سال: 2012
ISSN: 0165-0270
DOI: 10.1016/j.jneumeth.2012.09.006